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The effects of cannabinoids on the brain. The acute effects of cannabinoids as well as the development of tolerance are mediated by G protein-coupled cannabinoid receptors. The CB1 receptor and its splice variant CB1A, are found predominantly in the brain with highest densities in the hippocampus, cerebellum and striatum. Cannabinoid - Wikipedia The human brain has more cannabinoid receptors than any other G protein-coupled receptor (GPCR) type. Cannabinoid receptor type 1. CB 1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic system, including the hippocampus and the striatum. They are also found in the cerebellum and in ... Cannabinoid receptor - Wikipedia All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds. There are currently two known subtypes of cannabinoid receptors, termed CB 1 and CB 2. The CB 1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys.
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